Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Research advances on alpha-fetoprotein physiological function and clinical potential].

Zheng-Feng Yin1, Cui-Hong Wang

  • 1Molecular Oncology Research Laboratory, Eastern Hepatobilliary Surgery Hospital, Second Military Medical University, Shanghai 200438, P. R. China. yinzfk@online.sh.cn

AI Zheng = Aizheng = Chinese Journal of Cancer
|February 4, 2003
PubMed
Summary

Alpha-fetoprotein (AFP) is a fetal protein used as a tumor marker. It also functions in ligand transport, growth regulation, and as a potential drug carrier for cancer chemoprevention.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>Ab initio</i> study revealing remarkable oscillatory effects and negative differential resistance in the molecular device of silicon carbide chains.

Physical chemistry chemical physics : PCCP·2023
Same author

Anti-tumor activity and mechanism of oligoclonal hepatocellular carcinoma tumor-infiltrating lymphocytes <i>in vivo</i> and <i>in vitro</i>.

Cancer biology & therapy·2019
Same author

Facile construction of organometallic rotaxane-terminated dendrimers using neutral platinum-acetylides as the main scaffold.

Chemical communications (Cambridge, England)·2018
Same author

Activation of Chiral (Salen)AlCl Complex by Phosphorane for Highly Enantioselective Cyanosilylation of Ketones and Enones.

Journal of the American Chemical Society·2015
Same author

A neutral branched platinum-acetylide complex possessing a tetraphenylethylene core: preparation of a luminescent organometallic gelator and its unexpected spectroscopic behaviour during sol-to-gel transition.

Chemical communications (Cambridge, England)·2015
Same author

Improved method increases sensitivity for circulating hepatocellular carcinoma cells.

World journal of gastroenterology·2015

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Context:

  • Alpha-fetoprotein (AFP) is recognized as a fetal protein with established roles as a serum marker for monitoring fetal defects and tumor progression.
  • Beyond its diagnostic utility, AFP possesses significant physiological functions that are increasingly being elucidated.
  • Its involvement in binding and transporting various ligands, including fatty acids, steroids, and environmental contaminants, highlights its versatile molecular interactions.

Purpose:

  • To explore the multifaceted physiological roles of Alpha-fetoprotein (AFP) beyond its established function as a tumor marker.
  • To investigate the mechanisms underlying AFP's dose-dependent growth regulatory functions, including apoptotic and signaling pathway modulation.
  • To evaluate the potential of AFP as a targeted drug delivery system for cancer therapy and as a chemopreventive agent.

Related Experiment Videos

Summary:

  • AFP acts as a crucial binding and transporting protein for diverse ligands such as fatty acids, steroids, and heavy metal ions.
  • Its role as a growth regulator is dose-dependent, influencing cellular processes through apoptosis and signal transduction modulation.
  • AFP demonstrates potential as an anticancer drug carrier by targeting AFP receptors on tumor cells, enhancing therapeutic efficiency.
  • Furthermore, AFP exhibits growth-suppressive properties, suggesting its utility in chemoprevention strategies for breast and other cancers.

Impact:

  • This research expands the understanding of Alpha-fetoprotein's biological significance, revealing its potential beyond a simple tumor marker.
  • The findings support the development of novel therapeutic strategies utilizing AFP for targeted drug delivery and cancer chemoprevention.
  • Further investigation into AFP's regulatory mechanisms could unlock new avenues for cancer treatment and disease management.