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Determination of Tolerable Fatty Acids and Cholera Toxin Concentrations Using Human Intestinal Epithelial Cells and BALB/c Mouse Macrophages
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Published on: May 30, 2013

Epidemiology of cholera--a five year study

J K Bajaj1, V P Baradker, S G Joshi

  • 1Deptt of Microbiology, Govt. Medical College, Aurangabad-431001.

The Journal of Communicable Diseases
|February 4, 2003
PubMed

Insights

This study analyzed 286 Vibrio cholerae strains over five years. Results show shifts in serogroups (O1 and O-139) and serotypes (Ogawa and Inaba), potentially influenced by population immunity.

Area of Science:

  • Microbiology
  • Epidemiology
  • Immunology

Background:

  • Cholera remains a significant public health concern globally.
  • Understanding Vibrio cholerae serotype dynamics is crucial for effective disease control.

Purpose of the Study:

  • To investigate the serotype distribution and temporal shifts of Vibrio cholerae strains over a five-year period.
  • To identify demographic patterns associated with cholera infections.

Main Methods:

  • Isolation and identification of 286 Vibrio cholerae strains using standard microbiological techniques.
  • Serological confirmation through slide agglutination tests with specific antisera (polyvalent, Ogawa, Inaba, O-139).

Main Results:

  • The majority of infections occurred in children aged 0-10 years, with a higher incidence in females.
  • Vibrio cholerae O-139 was detected in 1998 and 2000; serotype Inaba was isolated only in 1999.
  • All other isolates belonged to the Ogawa serotype, indicating a periodic shift between O1 and O-139 serogroups.

Conclusions:

  • The observed periodic shifts between O1 and O-139 serogroups, and between Ogawa and Inaba serotypes, may be driven by population immunity and immune pressure.
  • These findings highlight the evolving epidemiology of Vibrio cholerae and the need for ongoing surveillance.

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