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Related Experiment Videos

[Study on the hypotensive effect of manascus].

M Sun1, Y Li, W Yan

  • 1Institute of Food Safety Control and Inspection, Beijing 100021, China.

Wei Sheng Yan Jiu = Journal of Hygiene Research
|February 4, 2003
PubMed
Summary

Manascus demonstrated a hypotensive effect in spontaneously hypertensive rats and DOCA-salt hypertensive rats, with a more potent impact observed in the latter. Its effect was less pronounced in renalvascular hypertensive rats.

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Area of Science:

  • Pharmacology
  • Cardiovascular Research
  • Natural Products

Context:

  • Hypertension is a prevalent cardiovascular condition.
  • Established rat models are crucial for studying antihypertensive agents.
  • Manascus is a natural product with potential therapeutic properties.

Purpose:

  • To evaluate the antihypertensive efficacy of Manascus.
  • To compare the effects of Manascus across different hypertension models.
  • To determine the dose-dependent hypotensive effect of Manascus.

Summary:

  • Manascus was administered to spontaneously hypertensive rats (SHR), renalvascular hypertensive rats (RHR), and DOCA-salt hypertensive rats at varying doses (0.4-1.2 g/kg BW).
  • Systolic blood pressure and heart rate were monitored weekly.

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  • A significant hypotensive effect was observed in SHR and DOCA-salt hypertensive rats, with a more pronounced effect in DOCA-salt rats. Manascus showed limited efficacy in RHR.

    • Impact:

    • Manascus exhibits potential as a natural antihypertensive agent.
    • The study highlights differential efficacy across hypertension models.
    • Further research into Manascus's mechanism of action is warranted.