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Relationship between HAART adherence and adipose tissue alterations.
Adriana Ammassari1, Andrea Antinori, Alessandro Cozzi-Lepri
1Clinica delle Malattie Infettive, Università Cattolica del S. Cuore, Roma, Italy. aammassari@libero.it
Journal of Acquired Immune Deficiency Syndromes (1999)
|February 4, 2003
Summary
Adherence to highly active antiretroviral therapy (HAART) can lead to adipose tissue alterations (ATA). Patient-perceived ATA may decrease HAART adherence, highlighting a complex interplay impacting treatment outcomes.
Area of Science:
- HIV/AIDS research
- Pharmacology
- Metabolic disorders
Background:
- Adipose tissue alterations (ATA) are common in patients on highly active antiretroviral therapy (HAART).
- ATA can negatively impact quality of life and adherence to HAART.
- Previous studies were cross-sectional, limiting causal inference.
Purpose of the Study:
- To evaluate the longitudinal relationship between ATA and adherence to HAART.
- To investigate the bidirectional interaction between ATA and HAART adherence over time.
Main Methods:
- Longitudinal analysis of participants from the Italian Cohort Naive Antiretrovirals (ICoNA) substudies (AdICoNA and LipolCoNA).
- Adherence assessed via a 16-item self-administered questionnaire.
- ATA diagnosed by physicians and self-perceived by patients; both evaluated longitudinally.
Main Results:
- Good baseline adherence increased the likelihood of developing ATA (RH = 2.58).
- Self-perceived ATA at baseline was a significant predictor of subsequent nonadherence (OR, 4.67).
- Clinically diagnosed ATA was not significantly associated with future nonadherence (OR, 0.77).
Conclusions:
- HAART adherence and ATA exhibit a dynamic, interactive relationship.
- Higher adherence may increase the risk of developing ATA.
- Patient-reported ATA can negatively affect subsequent HAART adherence.