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Arsenic and cancer.

R Jackson, J W Grainge

    Canadian Medical Association Journal
    |September 6, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Long-term ingestion of inorganic arsenic can lead to skin issues like palmar and plantar keratoses and increase the risk of skin cancers, including basal cell carcinoma. Arsenic exposure may also be linked to other systemic cancers.

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    Area of Science:

    • Toxicology
    • Dermatology
    • Oncology

    Background:

    • Arsenic exposure, particularly from environmental sources, remains a public health concern.
    • Long-term exposure to inorganic arsenic has been associated with various adverse health effects.

    Purpose of the Study:

    • To investigate the link between chronic inorganic arsenic ingestion and the development of skin conditions and cancers.
    • To review existing literature on arsenic-induced keratoses and malignancies.

    Main Methods:

    • Case study of seven patients with palmar and plantar keratoses following arsenic ingestion.
    • Review of medical literature on arsenic exposure and associated cancers.

    Main Results:

    • Seven patients developed palmar and plantar keratoses years after arsenic ingestion.

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  • Six patients developed skin cancers, including basal cell carcinoma, squamous cell carcinoma, and carcinoma in situ.
  • Two patients developed systemic cancers: breast adenocarcinoma and colon carcinoma.

    • Conclusions:

    • Long-term inorganic arsenic ingestion is strongly linked to palmar and plantar keratoses and skin cancers, especially superficial multicentric basal cell carcinoma.
    • Arsenic ingestion is suspected, though not proven, to cause other systemic cancers.
    • Despite decreased general exposure, arsenic can still be found in drinking water, food, and cigarette smoke.