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Malignant perivascular epithelioid cell tumor involving the prostate
Chin-Chen Pan1, An-Hang Yang, Hung Chiang
1Department of Pathology, National Yang-Ming University, and Veterans General Hospital-Taipei, Taipei, Taiwan. ccpan@vghtpe.gov.tw
Archives of Pathology & Laboratory Medicine
|February 4, 2003
Abstract:
Perivascular epithelioid cell tumor (PEComa) is a neoplasm chiefly composed of HMB-45-positive epithelioid cells with clear-to-granular cytoplasm and a perivascular distribution. We describe such a tumor involving the prostate and seminal vesicle in a 46-year-old man. The tumor had characteristic histologic features of PEComa. Immunohistochemically, the tumor cells were positive for HMB-45 but negative for epithelial markers, Melan-A, and S100 protein. The tumor behaved in a malignant fashion, and the patient died of the disease 4 years after diagnosis.