Small, dense low-density lipoprotein: risk or myth?
Related Experiment Video
Updated: Aug 13, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
1Emory Lipid Research Laboratory, Emory University School of Medicine, Atlanta Veterans Affairs Medical Center, 1670 Clairmont Road, Mail Code 151, Decatur, GA 30033, USA. ale@emory.edu
Abstract:
Based on the particle diameter of the major subpopulation of low-density lipoprotein (LDL) in plasma, an individual may be classified either as having phenotype A (desirable phenotype; large, buoyant LDL) or phenotype B (high risk; small, dense LDL). This article reviews the clinical significance of LDL particle diameter determination and proposes a strategy for incorporating this information in the new guidelines of the National Cholesterol Education Program's Adult Treatment Panel III.
Related Concept Videos
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
Lipids: Dietary Sources and Requirements
Overview of Lipid Metabolism
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Cholesterol: Significance and Regulation
Considering cholesterol and...
Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Coronary Artery Disease IV: Preventive Measures

