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Taxane-induced nail changes: incidence, clinical presentation and outcome
A M Minisini1, A Tosti, A F Sobrero
1Clinical Oncology, University of Udine, Udine, Italy.
Summary
Taxane chemotherapy can cause various nail changes, including pigmentation, hematoma, Beau
Area of Science:
- Oncology
- Dermatology
Background:
- Taxane chemotherapy is a cornerstone in treating various cancers.
- Nail changes are a known, albeit often underreported, side effect of chemotherapy.
Observation:
- This study describes clinical characteristics of nail changes in seven patients undergoing taxane-containing chemotherapy.
- Observed changes included nail pigmentation, subungual hematoma, Beau's lines, onycholysis, and subungual suppuration.
Findings:
- The incidence of these taxane-induced nail changes, based on a Medline literature review, ranges from 0% to 44%.
Implications:
- Awareness of these potential nail toxicities is crucial for oncologists and dermatologists.
- Monitoring and managing nail changes can improve patient quality of life during chemotherapy.