Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Leptospiral nephropathy.

Visith Sitprija1, Kitti Losuwanrak, Talerngsak Kanjanabuch

  • 1Queen Saovabha Memorial Institute, Bangkok, Thailand. visith@redcross.or.th

Seminars in Nephrology
|February 4, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to: "COVID-19 monitoring with sparse sampling of sewered and non-sewered wastewater in urban and rural communities" [iScience, Volume 26, Issue 7 (2023) 107019].

iScience·2026
Same author

Distinct pathophysiological mechanisms of <i>Heterometrus laoticus</i> and <i>Lychas mucronatus</i> scorpion venoms on cardiovascular and renal functions.

The journal of venomous animals and toxins including tropical diseases·2026
Same author

When the Water Stops: Dialysis Service Disruption During Catastrophic Urban Flooding in Southern Thailand.

Kidney international reports·2026
Same author

Crescentic IgM-κ Monoclonal Immunoglobulin Deposition Disease with Thrombotic Microangiopathy in Waldenström's Macroglobulinemia: A Rare and Aggressive Monoclonal Gammopathy of Renal Significance Presentation - A Case Report and Literature Review.

Glomerular diseases·2026
Same author

Regional Variation of Aetiologies and Complications in Chronic Kidney Disease From Thailand (THAI-CKD Registry).

Nephrology (Carlton, Vic.)·2026
Same author

Dual RAAS blockade preserves peritoneal membrane function and residual kidney function in incident peritoneal dialysis patients: a randomized controlled trial.

Journal of nephrology·2026
Same journal

Current Options for Kidney Protection: Are Renin-Angiotensin System Inhibitors Still Relevant?

Seminars in nephrology·2026
Same journal

Proposed Role for Quantitative Podocyturia as a Clinical Marker of Systemic Endothelial Injury: Implications for Cardiovascular Disease and Longevity.

Seminars in nephrology·2026
Same journal

Kidney Protection Options in 2025: Are Renin-Angiotensin System Inhibitors Still Needed?

Seminars in nephrology·2026
Same journal

From Nephron Number to Global Health.

Seminars in nephrology·2026
Same journal

Chronic Kidney Disease Progression Mechanisms: Why They Matter in an Era of Novel Kidney Protective Therapies.

Seminars in nephrology·2026
Same journal

Of Diuretics, Transporters, and Mechanisms of Hypertension.

Seminars in nephrology·2026
See all related articles

Leptospirosis frequently affects the kidneys, causing acute renal failure in many patients. Early recognition of severe hypotension is crucial for managing renal and pulmonary complications.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Pathology

Background:

  • Renal involvement is a common complication of leptospirosis, ranging from mild urinary changes to severe acute renal failure.
  • Hypokalemia and severe hypotension are frequently observed, with hypotension serving as a critical warning sign for subsequent renal and pulmonary issues.

Purpose of the Study:

  • To elucidate the pathological mechanisms and clinical manifestations of renal involvement in leptospirosis.
  • To identify key indicators for predicting severe outcomes and to understand the factors contributing to renal dysfunction.

Main Methods:

  • Review of clinical data and pathological findings in leptospirosis patients with renal complications.
  • Analysis of factors influencing renal failure, including hemodynamic changes, immune responses, and direct nephrotoxicity.

Related Experiment Videos

Main Results:

  • Acute renal failure affects 44%–67% of leptospirosis patients, with interstitial nephritis and tubular necrosis being the primary renal lesions.
  • Hemodynamic alterations, immune responses, bacterial factors, and cytokine generation contribute to renal injury; glomerular changes are typically minor.
  • Pulmonary complications, particularly hemorrhage and acute respiratory distress syndrome, significantly worsen the prognosis.

Conclusions:

  • Leptospirosis commonly leads to significant renal dysfunction primarily through interstitial nephritis and tubular necrosis.
  • Understanding the interplay of hemodynamic, immune, and toxic factors is vital for managing leptospirosis-associated kidney disease.
  • Prompt identification of hypotension is essential for improving patient outcomes and preventing severe complications.