Related Experiment Video
Updated: Sep 27, 2026

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
Published on: March 14, 2011
Allogeneic stem cell transplantation for chronic myeloid leukemia
1Stem Cell Allotransplantation Section, Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Abstract:
Allogeneic stem cell transplantation (SCT) plays a central role in chronic myeloid leukemia (CML) because it remains the only treatment with proven curative potential. For this reason, SCT has been more frequently performed in CML than in any other disease. The susceptibility of CML to the graft-versus-leukemia (GVL) effect and our ability to monitor minimal residual disease are particular features that place this disease at the forefront of GVL research. This review describes the mechanism of cure of CML by SCT, current results of transplantation, factors determining outcome, management of relapsed or persistent disease, and recent treatment advances.
Related Concept Videos
Stem Cell Therapy for Tissue Regeneration
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

