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Renal aquaporin water channels: from molecules to human disease
Robert W Schrier1, Melissa A Cadnapaphornchai
1Department of Medicine, University of Colorado School of Medicine, 4200 East Ninth Avenue, Box B178, Denver, CO 80262, USA. Robert.Schrier@uchsc.edu
Progress in Biophysics and Molecular Biology
|February 5, 2003
Abstract:
Following the discovery of the aquaporin-1 water channel in 1991, molecular techniques have been developed to examine the roles of renal aquaporins-1, -2, -3, and -4 in disorders of water balance. This article reviews current knowledge regarding aquaporin function and dysfunction in water-losing and water-retaining states.