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Synthesis and evaluation of delta-lactams (piperazones) as elastase inhibitors
Jürgen Seibel1, David Brown, Augustin Amour
1The Oxford Centre for Molecular Sciences and The Dyson Perrins Laboratory, South Parks Road, Oxford OX1 3QY, UK.
Bioorganic & Medicinal Chemistry Letters
|February 5, 2003
Abstract:
A series of monocyclic delta-lactams (piperazones) was prepared and analysed as inhibitors of porcine pancreatic elastase and human neutrophil elastase.