Related Experiment Videos
Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series
Scott H Watterson1, Marianne Carlsen, T G Murali Dhar
1Bristol-Myers Squibb PRI, PO Box 400, Princeton, NJ 08543-4000, USA. scott.waterson@bms.com
Bioorganic & Medicinal Chemistry Letters
|February 5, 2003
Abstract:
A series of novel quinolone-based small molecule inhibitors of inosine monophosphate dehydrogenase (IMPDH) was explored. The synthesis and the structure-activity relationships (SARs) derived from in vitro studies are described.