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Related Experiment Videos

Connexins and secretion.

Véronique Serre-Beinier1, Christophe Mas, Alessandra Calabrese

  • 1Department of Morphology, University of Geneva, Medical School, C.M.U., 1 rue Michel Servet, 1211 4, Genève, Switzerland.

Biology of the Cell
|February 5, 2003
PubMed
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Connexins form gap junctions essential for gland function, regulating secretory cell growth and product release. Recent evidence highlights their crucial roles in controlling gene expression and differentiated functions within glands.

Area of Science:

  • Cell biology
  • Endocrinology
  • Exocrinology

Background:

  • Connexin channels at gap junctions are vital in all studied macroscopic endocrine and exocrine glands.
  • These channels connect secretory cells, influencing their growth, gene expression, and function.
  • Previous reviews established connexins' roles, but new evidence necessitates an update.

Purpose of the Study:

  • To review novel evidence supporting the multiple regulatory roles of connexins in glands.
  • To identify open questions and discuss future perspectives in the field of gland connexin research.

Main Methods:

  • Literature review of recent studies on connexins in endocrine and exocrine glands.
  • Analysis of evidence for connexin involvement in secretory cell regulation.

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  • Discussion of emerging research directions and unresolved questions.

    • Main Results:

    • Connexins play significant roles in controlling secretory cell proliferation and differentiation.
    • Cell-to-cell communication via connexins is critical for regulated biosynthesis and release of secretory products.
    • New evidence reinforces the multifaceted regulatory functions of connexins in glandular tissues.

    Conclusions:

    • Connexins are key regulators of secretory cell function, impacting growth, gene expression, and product release.
    • Further research is needed to fully elucidate the complex roles of connexins and address outstanding questions in glandular biology.
    • The field offers promising perspectives for understanding and potentially manipulating gland function through connexin modulation.