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Rostral anterior cingulate cortex dysfunction during error processing in schizophrenia.

Kristin R Laurens1, Elton T C Ngan, Alan T Bates

  • 1Department of Psychiatry, University of British Columbia, Vancouver, Canada.

Brain : a Journal of Neurology
|February 5, 2003
PubMed
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Patients with schizophrenia show reduced brain activity in the rostral anterior cingulate cortex (ACC) during error processing. This suggests a disturbed affective or motivational response to errors in schizophrenia.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Schizophrenia is associated with impaired internal monitoring of erroneous responses.
  • Healthy adults exhibit an error negativity (Ne) or error-related negativity (ERN) during erroneous responses.
  • Patients with schizophrenia show a reduced Ne/ERN amplitude during errors of commission (EoC).

Purpose of the Study:

  • To investigate brain activity associated with errors of commission (EoC) in schizophrenia using event-related fMRI.
  • To compare brain activity during error processing between patients with schizophrenia and healthy participants.

Main Methods:

  • Event-related functional MRI (fMRI) was used.
  • Participants included 10 patients with schizophrenia and 16 matched healthy controls.

Related Experiment Videos

  • A Go/NoGo task variant was employed to elicit errors of commission.

    • Main Results:

    • Patients with schizophrenia exhibited relative underactivity in the rostral anterior cingulate cortex (ACC) during EoC compared to healthy participants.
    • Widespread underactivity in the limbic system was observed in patients with schizophrenia.
    • Hyperactivity in bilateral parietal cortex was noted in patients during both EoC and correctly rejected trials.

    Conclusions:

    • Findings align with previous ERP research indicating functional abnormalities in error processing in schizophrenia.
    • Reduced rostral ACC and limbic activity suggest a disturbed affective or motivational response to errors in schizophrenia.
    • Parietal cortex hyperactivity may reflect compensatory mechanisms or altered attentional processes.