[Histological findings in parabiosis with crossed digestive tubes]

Microscopic examination of organs from outbred and inbred rats used in 5 groups for experiments in parabiosis with and without crossing of the digestive tubes and pseudoparabiosis showed that skin junctions soon became dehiscent, with boundary furrows tendings to separate the animals, in outbred rats, whereas continuity was not lost throughout the experiment in inbred rats, whereas continuity was not lost throughout the experiment in inbred animals. Juncture with abundant connective tissue rich in small-cell infiltrates was noted in intestinal anastomoses between outbreds, followed by dehiscence or incomplte junction. In inbred animals, junctions persisted till death; these were usually less abud nant than in anastomoses after section in the same animal. Serious steatoticonecrotic liver and amyloidotic kidney alterations were noted in all animals in parabiosis and pseudoparabiosis. These were more marker in inbred animals and appeared to have been responsible for death in cases where dehiscence and peritonitis did not take place. These histopathological pictures - also noted in inbred rats in pseudoparabiosis (i. e. kept together by nylon nets only) - make it impossible to say whether crossing of the digestive tubes is per se a cause of lesions. The experimentation of another parabiosis technique is proposed.