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Related Experiment Videos

Acne in infancy and acne genetics.

Maria I Herane1, Iwao Ando

  • 1Department of Dermatology, West Unit Faculty of Medicine, Hospital San Juan de Dios, University of Chile, Santiago, Chile. giderm@yahoo.es

Dermatology (Basel, Switzerland)
|February 5, 2003
PubMed
Summary

Acne manifests across all ages, from infancy to adulthood, with varying causes like sebum production and androgens. Genetic factors and specific gene variations significantly influence acne development and severity.

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Area of Science:

  • Dermatology
  • Genetics
  • Endocrinology

Background:

  • Acne vulgaris is a common skin condition affecting individuals from infancy through adulthood.
  • Pathogenesis varies by age, involving sebum excretion, androgens, and genetic predispositions.

Purpose of the Study:

  • To review the multifaceted causes and genetic underpinnings of acne across different age groups.
  • To highlight key predictors for severe acne in prepubertal children.

Main Methods:

  • Literature review of acne pathogenesis across neonatal, infantile, prepubertal, adolescent, and postadolescent stages.
  • Analysis of genetic factors, including hereditary influences and specific gene polymorphisms.

Main Results:

  • Neonatal and infantile acne are linked to sebum production and androgens.
  • Early comedones and high dehydroepiandrosterone sulfate predict severe prepubertal acne.
  • Genetic factors, chromosomal abnormalities, and gene polymorphisms (CYP1A1, MUC1) are implicated in acne pathogenesis.

Conclusions:

  • Acne's development is influenced by a combination of age-specific factors and significant genetic contributions.
  • Understanding these mechanisms is crucial for predicting and managing acne severity.

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