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Updated: Sep 15, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Studies on the thermal decomposition process and kinetics of purine drugs
Jian Zhang1, Rui-long Sheng, Wen-peng Mai
1College of Chemistry and Life Sciences, South-central University for Nationalities, Wuhan 430074, China.
Aim:
To study the thermal stability, decomposition process and kinetics of such purine pharmaceuticals as aciclovir (Acv), penciclovir (Pcv), and their parent substance, guanine.
Methods:
Using infrared technique, accelerating test method and thermogravimetry to investigate the thermal decomposition processes and using Coast-Redfern method, MKN method and Ozawa method to deal with the data to get kinetic functions.
Results:
The decomposition process and the formed products were derived, the kinetic model function was suggested by comparison of the kinetic parameters.
Conclusion:
Pcv and Acv's degrading product for the first step is guanine. The sequences of their thermal stabilities is: Pcv > Acv. The two drugs' kinetic equation of thermal decomposition is expressed as: da/dt = Ae-Ea/RT2(1-alpha)3/2.
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