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[Preparation of sterically stabilized liposomes containing all-trans retinoic acid]
1Zhongkun Pharmaceutical Research Institute, China Pharmaceutical University, Nanjing 210009, China.
Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|February 6, 2003
Abstract
Aim:
To prepare sterically stabilized liposomes containing all-trans retinoic acid, and to study its physicochemical properties.
Methods:
The microstructure, the particle size and its distribution was determined by DSC, 1HNMR and 90 Plus Particle Size Analyzer and a TEM photo was taken.
Results:
The size of conventional liposomes and sterically stabilized liposomes were about 0.35 and 0.42 micron. The sterically stabilized structure can be confirmed by TEM photo.
Conclusion:
The stericallly stabilized liposomes containing all-trans retinoic acid can be prepared by combination of film-casting and freeze-drying.