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Reduced levels of MMP-2 and TIMP-1 in dyssegmental dysplasia

Kiyoshi Uchide1, Hirohisa Ueno, Noboru Takizawa

  • 1Department of Obstetrics and Gynecology, School of Medicine, Kanazawa University, Kanazawa, Japan. k-uchide@med.kanazawa-u.ac.jp

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
|February 6, 2003
PubMed

Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) were measured in a mild case of dyssegmental dysplasia. X-ray pictures of a female baby born vaginally at 39 weeks of gestation showed short, bent, dumbbell-shaped long bones of the limbs and profound dyssegmental ossification in the spine, findings characteristic of dyssegmental dysplasia. When the levels of MMP-1, MMP-2, MMP-9, TIMP-1, and TIMP-2 were measured, the levels of MMP-2 and TIMP-1 were significantly reduced. This case might provide a clue to disclose the etiology of dyssegmental dysplasia.

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