Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A new microencapsulation device for controlled membrane and capsule size distributions.

I Ceausoglu1, D Hunkeler

  • 1Laboratory of Polyelectrolytes and BioMacromolecules, Swiss Federal Institute of Technology, CH-1015 Lausanne, Switzerland.

Journal of Microencapsulation
|February 6, 2003
PubMed
Summary

This study presents novel devices for producing high-quality microcapsules for bioactive material encapsulation. These systems ensure precise control over microcapsule characteristics, crucial for applications like transplantation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cross-sphere modelling to evaluate impacts of climate and land management changes on groundwater resources.

The Science of the total environment·2021
Same author

Identification, spatial extent and distribution of fugitive gas migration on the well pad scale.

The Science of the total environment·2018
Same author

Distinct Dual C-Cl Isotope Fractionation Patterns during Anaerobic Biodegradation of 1,2-Dichloroethane: Potential To Characterize Microbial Degradation in the Field.

Environmental science & technology·2017
Same author

Regional water quality patterns in an alluvial aquifer: direct and indirect influences of rivers.

Journal of contaminant hydrology·2014
Same author

The effects of acrylamide polyelectrolytes on aquatic organisms: relating toxicity to chain architecture.

Chemosphere·2014
Same author

Can soil gas VOCs be related to groundwater plumes based on their isotope signature?

Environmental science & technology·2013

Area of Science:

  • Biomaterials Engineering
  • Chemical Engineering
  • Drug Delivery Systems

Background:

  • Microcapsules are vital for encapsulating bioactive materials, requiring mechanical protection, controlled diffusion, and immune blocking for transplantation.
  • Key microcapsule characteristics include smoothness, sphericity, narrow size/thickness distributions, centered payloads, and minimized size for optimal diffusion.
  • Production processes must be sterile, repeatable, robust, harmless to bioactive materials, and achieve high output.

Purpose of the Study:

  • To develop and present two prototype devices for the controlled microencapsulation of bioactive materials.
  • To demonstrate the capability of these systems in producing microcapsules with specific, desirable properties.
  • To highlight advancements in microcapsule production technology, particularly regarding precision and efficiency.

Related Experiment Videos

Main Methods:

  • Development of a semi-manual device for small-scale, sterile microcapsule production with controlled properties.
  • Development of an 'automated reaction control' system for enhanced precision in microcapsule fabrication.
  • Utilized the alginate/cellulose sulphate/poly(methylene-co-guanidine) system for demonstrating the semi-manual device's capabilities.

Main Results:

  • The semi-manual device enabled repeatable production of 400 micrometer microcapsules.
  • Achieved a production rate of 500,000 microcapsules per hour.
  • Demonstrated a size distribution within +/-10% and membrane thickness distribution within +/-5 micrometers, surpassing existing technologies.

Conclusions:

  • The developed microencapsulation devices offer precise control over microcapsule properties.
  • The automated system provides superior membrane thickness control compared to current technologies.
  • These advancements hold significant potential for improving bioactive material delivery and transplantation applications.