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[Role of thyroid hormone in peripheral nerve regeneration]
1Department of Orthopedic Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing, P. R. China 400037.
Objective:
To review the role of thyroid hormone in the peripheral nerve regeneration.
Methods:
The recent literatures of experimental study and clinical application on the role of thyroid hormone in nerve regeneration were reviewed. The researches on expression, isoform and changes of thyroid hormones in rat sciatic nerve in normal or injury were summarized. The effect of thyroid hormone on local rat sciatic nerve was studied, too.
Results:
Nuclear thyroid hormone receptors expressed in numerous nuclei of sciatic nerve during a limited period of development extending from the third week of embryonic life to the end of the second postnatal week and after injury of adult sciatic nerve. A single and local administration of thyroid hormone at the level of the transected sciatic nerve produced a lasting effect on peripheral nerve regeneration.
Conclusion:
The beneficial effects of thyroid hormones upon injured peripheral nerve may have considerable therapeutic potential.