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Updated: Aug 17, 2026
In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Published on: August 12, 2017
[Animal model of immunologic change detection in vivo after xenotransplantation]
1Laboratory of Transplant Engineering and Transplant Immunology, West China Hospital, Sichuan University, Chengdu Sichuan, P. R. China 610041.
Objective:
To review the current condition, test method and progress of the animal model of xeno-graft-versus-host disease(xeno-GVHD).
Methods:
The literature review and comprehensive analysis methods were used in this article.
Results:
Implanted immunologic cells, the recepient had the chance of showing host-versus-graft reaction, GVHD or microchimerism. Now, xeno-GVHD could be induced in vivo at small and large animals, it also could be supervised through many ways.
Conclusion:
Chimeric cells is very important to xeno-GVHD animal model. With this model, we can really mimic the immunologic change in vivo after xenotransplantation.
