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Assisting functional assignment for hypothetical Heamophilus influenzae gene products through structural genomics
Gary L Gilliland1, Alexey Teplyakov, Galina Obmolova
1Center for Advanced Research in Biotechnology of the University of Maryland Biotechnology Institute and the National Institute of Standards and Technology, 9600 Gudelsky Drive, Rockville, MD 20850, USA. gary.gilliland@nist.gov
Current Drug Targets. Infectious Disorders
|February 7, 2003
Summary
Structural genomics is determining Haemophilus influenzae protein structures to assign biological functions. Experimentally solved structures aid in functional understanding and identify potential drug targets.
Area of Science:
- Structural biology
- Genomics
- Protein science
Background:
- Many Haemophilus influenzae proteins have unknown biological functions.
- Structural genomics projects aim to determine protein structures to aid functional assignment.
Purpose of the Study:
- To determine the three-dimensional structures of unknown Haemophilus influenzae proteins.
- To investigate if structural information can help assign protein functions.
- To identify potential new drug development targets.
Main Methods:
- Crystallography
- Nuclear Magnetic Resonance (NMR) spectroscopy
- Structural genomics approach
Main Results:
- Over twenty-five protein structures have been determined.
- Experimentally solved structures provide insights for functional assignment.
- The approach successfully guides further functional studies.
Conclusions:
- Structural information is valuable for deducing protein function.
- This structural genomics effort identifies potential new drug targets for development.