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Inhibitors of lysine biosynthesis as antibacterial agents
Craig A Hutton1, Timothy J Southwood, Jennifer J Turner
1School of Chemistry, The University of Sydney, NSW 2006, Australia. c.hutton@chem.usyd.edu.au
Mini Reviews in Medicinal Chemistry
|February 7, 2003
Abstract:
Bacterial biosynthesis of lysine has come under increased scrutiny as a target for novel antibacterial agents as it provides both lysine for protein synthesis and meso-diaminopimelate for construction of the bacterial peptidoglycan cell wall. Recent studies of the enzymes of the lysine biosynthetic pathway, development of inhibitors and investigations of their antibacterial properties are discussed.