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Related Experiment Videos

Genomics and homeostasis.

Allen W Cowley1

  • 1Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
|February 7, 2003
PubMed
Summary
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Genomic sequencing is revolutionizing 21st-century physiology by linking genes to complex organism functions. New tools and techniques are enabling a deeper understanding of cardiovascular and renal systems.

Area of Science:

  • Genomics
  • Systems Biology
  • Physiology

Background:

  • The integration of DNA sequence knowledge is transforming 21st-century physiology.
  • Physiologists face challenges and opportunities in connecting gene data to organism functions.

Discussion:

  • Genomic systems biology maps for cardiovascular and renal function are emerging.
  • Physiological profiling aids in hypothesizing gene-pathway relationships.
  • Chromosomal substitution techniques (consomic and congenic rats) validate linkage analysis and refine genetic targets.
  • Microarray analysis reveals gene expression patterns, enhancing systems physiology understanding.

Key Insights:

  • The first comprehensive genomic systems biology map for cardiovascular and renal function has been established.

Related Experiment Videos

  • Novel tools like "physiological profiling" facilitate hypothesis generation regarding gene regulation.
  • Advanced techniques are bridging the gap between genetic information and physiological processes.

    • Outlook:

    • Connecting approximately 36,000 genes to complex mammalian system functions is an ongoing endeavor.
    • The field is poised for significant advancements in understanding gene-environment-physiology interactions.
    • Future research will likely focus on translating genomic insights into clinical applications for disease.