Related Experiment Video
Updated: Jul 17, 2026
A Rat Dry Eye Model with Lacrimal Gland Dysfunction Induced by Scopolamine
Published on: February 9, 2024
[Lacunar folds study in dry eye diagnosis]
J S López García1, I García Lozano, J Martínez Garchitorena
1Hospital Central Cruz Roja, Madrid. España.
Purpose:
To determine the diagnostic value of lacunar folds study in patients with dry eye syndrome.
Methods:
We present a prospective study in 185 patients (91 males and 94 females). In all patients the abduction degree was measured after instilling a fluorescein drop, which makes lacunar folds disappear. We divided patients into two groups, one of them with dry eye symptoms and the other without them. The symptomatic group was divided into four other subgroups, according to the severity of symptoms.
Results:
We found significant differences in the early disappearing of lacunar folds in dry eye patients compared with the control group. The folds disappeared quicker when the symptoms were more severe. The disappearance of folds is significantly associated with the Schirmer test and with the break up time test (BUT).
Conclusions:
Lacunar folds study should be included as a useful and easy test in the diagnosis of dry eye syndrome, nevertheless its disappearance is not exclusive of this disease.
