A case of pseudo-aprosencephaly
Maria Dambska1, Anna Taraszewska, Tamara Czwalińska
1Department of Developmental Neuropathology, Polish Academy of Sciences, Warszawa, Poland. folia@cmdik.pan.pl
Abstract:
We present a case of rare, severe brain malformations. In a microcephalic premature newborn only a small structure found in the base of the cranium corresponded to the prosencephalic part of the brain. The basal ganglia were lacking and the cortico-subcortical area changed into empty vesicles with only small fragments of cortical stripe. This picture authorises us to speak on the probably complex pathomechanism of anomalies: genetically caused malformations including underdevelopment of telencephalic nuclei and additional occurrence of extrinsic lesions leading to pseudo-aprosencephaly formation.
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