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Related Experiment Videos

Antisense transcripts at the EMX2 locus in human and mouse.

Ferrin C Noonan1, Paul J Goodfellow, Lora J Staloch

  • 1Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.

Genomics
|February 8, 2003
PubMed
Summary
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A newly discovered EMX2 opposite strand (EMX2OS) transcript shares expression patterns with EMX2 in the endometrium. Both are reduced in tumors, suggesting a potential role for EMX2OS in endometrial cancer suppression.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • The homeodomain transcription factor EMX2 is crucial for development.
  • EMX2 is located at 10q26, a region associated with endometrial tumor suppressor activity.
  • A novel antisense transcript, EMX2OS, has been identified.
  • EMX2OS is transcribed from the opposite strand of EMX2 and overlaps its locus.

Purpose of the Study:

  • To characterize the novel EMX2OS transcript.
  • To investigate the expression patterns of EMX2 and EMX2OS in endometrial tissues.
  • To explore the potential functional relationship between EMX2 and EMX2OS.

Main Methods:

  • Transcript identification and characterization.
  • Analysis of alternative splicing in human and mouse orthologs.

Related Experiment Videos

  • Quantitative expression analysis of EMX2 and EMX2OS in normal and cancerous endometrial tissues.
  • Comparative analysis of human and murine orthologs.

    • Main Results:

    • A novel antisense transcript, EMX2OS, was identified, with an ortholog Emx2os in mice.
    • EMX2OS exhibits alternative splicing in humans but not mice.
    • Neither EMX2OS nor Emx2os has a significant open reading frame, and primary sequence is not conserved.
    • EMX2 and EMX2OS show coordinate expression in the endometrium, abundant in postmenopausal, reduced in premenopausal, and absent/reduced in tumors.
    • Identical expression patterns were observed for EMX2, EMX2OS, Emx2, and Emx2os in the uterine endometrium.

    Conclusions:

    • The conservation of EMX2OS and its coordinate expression with EMX2 suggests a biological function.
    • EMX2OS likely plays a role in regulating EMX2.
    • The shared expression pattern and reduction in endometrial tumors indicate a potential tumor suppressor role for the EMX2/EMX2OS axis.