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Updated: Sep 27, 2026

Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions
Published on: February 9, 2024
Color Doppler sonography in hypothyroidism
Susanne L Schulz1, Uwe Seeberger, Jürgen H Hengstmann
1Department of Medicine III, Vivantes Klinikum Am Urban, Dieffenbachstrasse 1, 10967 Berlin, Germany. susanne.schulz@kau-berlin.de
Insights
Color Doppler sonography reveals increased thyroid vascularization in hypothyroidism, correlating with autoimmune activity, not hormone production. This finding aids in understanding thyroid disease progression and diagnosis.
Area of Science:
- Endocrinology
- Radiology
- Immunology
Background:
- The diagnostic value of color Doppler sonography in thyroid diseases remains debated, with inconsistent study results.
- Limited research exists on color Doppler sonography's application in hypothyroidism.
Purpose of the Study:
- To evaluate the utility of color Doppler sonography in assessing hypothyroidism.
- To correlate sonographic findings with clinical and laboratory parameters in hypothyroid patients.
Main Methods:
- 89 patients with hypothyroidism underwent clinical examination, thyroid function tests, and color Doppler sonography.
- Thyroid parenchymal color flow distribution, intensity, and peak systolic velocity (PSV) were assessed.
- Color Doppler findings were graded (0-III) and correlated with clinical and laboratory data.
Main Results:
- 56 patients showed minimal vascularization (Pattern 0, PSV 22 cm/s), while 33 exhibited increased vascularization (Patterns I-III, PSV 39-63 cm/s).
- A strong correlation was observed between color intensity and anti-thyroid antibody levels (anti-Tg/anti-TPO).
- Thyroid volume and TSH levels correlated with vascularization, while duration of hypothyroidism showed an inverse correlation.
Conclusions:
- Intense thyroid hypervascularization, typically seen in hyperthyroidism, can also occur in hypothyroidism.
- Color Doppler findings reflect autoimmune process activity rather than stimulated thyroid hormone production.
Background:
The value of color Doppler sonography in thyroid disease continues to be a matter of debate. Over the past few years, several studies have proved unable to yield unequivocal results. Only a few studies concerning color Doppler sonography in patients with hypothyroidism have been published.
Methods:
89 patients with hypothyroidism have been evaluated. They were examined clinically; laboratory tests on thyroid function and color Doppler sonography have been performed. The color flow distribution and intensity were estimated and the fastest flow velocity (PSV) detectable with a pw-doppler was registered. The color pattern was graded from 0 to III as has been described by others and the color Doppler findings were then correlated to both the clinical picture and the laboratory results.
Results:
56 of the 89 hypothyroid patients showed pattern 0 with a PSV of 22 cm/s. In 33 patients different degrees of increased parenchymal color could be found with a concordant PSV: 16 patients showed pattern I with a PSV of 39 cm/s; 11 showed pattern II with PSV 58 cm/s, and 6 showed pattern III with PSV 63 cm/s. Regarding the corresponding clinical and laboratory variables, there was a very close correlation between color intensity and anti-Tg/anti-TPO antibody levels: pattern 0: anti-Tg 474 IU/ml, anti-TPO-Ab 810 IU/ml; pattern I: 1053/1733; pattern II: 1774/2432; pattern III: 1951/2633. Some correlation could also be found for the TSH values and the calculated volume of the thyroid gland, whereas the duration of hypothyroidism showed an inverse correlation to color intensity. (Pattern 0: TSH 3.1 mE/ml, volume 9.2 ml, duration 43 months; pattern I: 4.2 mE/l, 15.7 ml, 24 mos.; pattern II: 11.5 mE/l, 22.3 ml, 16 mos.; pattern III: 38.2 mE/l, 34.3 ml, 10 mos, respectively).
Conclusions:
The color Doppler pattern of intense hypervascularization of the thyroid gland formerly attributed only to the hyperthyroid state of active Graves' Disease can also be seen in hypothyroidism. Our data support the concept that the color flow appearance is not the result of stimulated thyroid hormone production, but a measure of the activity of an autoimmune process.
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