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Related Experiment Videos

Androgen physiology: unsolved problems at the millennium.

Jean D Wilson1, Michael W Leihy, Geoffrey Shaw

  • 1Medical Branch, Department of Internal Medicine, University of Texas Southwestern Medical Center, Room J6-110, 5323 Harry Hines Blvd, Dallas, TX 75390-8857, USA. jwils1@mednet.swmed.edu

Molecular and Cellular Endocrinology
|February 8, 2003
PubMed
Summary

Androgen physiology involves testosterone and dihydrotestosterone (DHT). DHT plays unique roles post-embryonic development, and marsupial mammals reveal distinct DHT formation mechanisms, with 5alpha-adiol potentially acting as a precursor.

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Area of Science:

  • Endocrinology
  • Developmental Biology
  • Steroid Hormone Research

Background:

  • Androgen physiology presents unique aspects compared to other steroid hormones.
  • Testosterone serves as both an active hormone and a prohormone for dihydrotestosterone (DHT).
  • DHT is crucial for embryonic development, amplifying hormonal signals, but its post-embryonic roles remain unclear.

Purpose of the Study:

  • To investigate the distinct roles of dihydrotestosterone (DHT) in post-embryonic life.
  • To explore alternative mechanisms of DHT formation, particularly in marsupial mammals.
  • To understand the function of 5alpha-androstane-3alpha, 17beta-diol (5alpha-adiol) in androgen action.

Main Methods:

  • Genetic studies and in vitro reporter gene assays to understand testosterone and DHT signaling.

Related Experiment Videos

  • Homologous recombination in mice to disrupt steroid 5alpha-reductase isoenzymes.
  • Analysis of androgen levels and administration of 5alpha-adiol in marsupial mammals (tammar wallaby).

    • Main Results:

    • DHT amplifies embryonic hormonal signals, with unique post-embryonic roles yet to be fully elucidated.
    • Marsupial mammals exhibit no sexual dimorphism in testosterone or DHT during male phenotype formation.
    • 5alpha-adiol administration to female marsupials caused significant virilization, suggesting its role as a DHT precursor.

    Conclusions:

    • Two distinct mechanisms for DHT formation in target tissues have evolved.
    • 5alpha-adiol may play a significant role in androgen action in neonatal mammals, warranting further investigation.
    • The precise functions of DHT in post-embryonic development require further research.