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Midtrimester triple-test levels in women with chronic hypertension and altered renal function
Simon Shenhav1, Ofer Gemer, Dan J Sherman
1Department of Obstetrics and Gynecology, Barzilai Medical Center, Ben-Gurion University of the Negev, Ashkelon 78306, Israel.
Objective:
To study the association between midtrimester triple-test levels and renal function in pregnant women with chronic hypertension.
Methods:
Forty-three patients with chronic hypertension for whom renal function was evaluated by the creatinine clearance test between 14- and 20-weeks gestation were studied. Midtrimester triple-test values obtained as part of Down screening program were correlated with renal function.
Results:
hCG correlated inversely with creatinine clearance (r = -0.345; p = 0.002) and directly with alpha-fetoprotein (r = 0.499; p = 0.003).
Conclusions:
In pregnant women with chronic hypertension, impaired renal function may alter midtrimester maternal serum hCG levels.
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