[A fluorimetric study of the interactions of hydrochloridum berberini with vinylpyrrolidone and beta-cyclodextrin]

The interactions of hydrochloridum berberini with 1-vinyl-2-pyrrolidone and beta-cyclodextrin in aqueous solution were studied by spectrofluorimetric method. The spectral changes were quantitatively investigated. Results showed that the complexation with beta-cyclodextrin resulted in an enhancement of the fluorescence of hydrochloridum berberini whereas 1-vinyl-2-pyrrolidone caused a quenching of the fluorescence. It had been supposed 1:1 complex formation. Specifically, formation constants and the thermodynamic parameters at different temperatures were calculated.