Related Experiment Video
Updated: Aug 15, 2026

Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice
Published on: May 13, 2019
[Congestive heart failure and paraoxonase]
1Department of Geriatrics, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Objective:
To determine the changes of paraoxonase activity in patients with heart failure.
Methods:
The serum paraoxonase (PON) activity of the heart failure group and controls was measured with phenylacetate as the substrate.
Results:
The serum PON activity of the heart failure patients significantly decreased as compared with the controls; after the treatment, the PON activity of heart failure was largely elevated; and the PON activity of the patients with heart failure was negatively correlated with tumor necrosis factor-alpha.
Conclusion:
The PON activity of patients with congestive heart failure significantly decreases.
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