[Study on syndrome pattern in insulin resistant model rats]

To explore the Syndrome pattern in insulin resistant model rats.

Eight Sprague-Dawley (SD) rats were induced to insulin resistance (IR) by 60% high-sucrose forage.

The correlative co-efficient of some biological and internal changes were clusterly analyzed and divided into 3 groups, which was closely related with phleg tubidity, blood stasis and internal toxin types respectively. The phlegm turbidity type was characterized by high content of blood lipid (triglyceride, total cholesterol) and high concentration of glycated serum protein; the blood stasis type was characterized by tendency of high viscosity and high coagulant state, the blood pressure increased, prothrombin time shortened, fibrinogen content raised and RBC and platelet count increased; while the internal toxin type was characterized by high content of glucose, insulin and the elevation of tumor necrosis factor.

The combined Syndrome of phlegm turbidity, blood stasis and internal toxin is the Syndrome-pattern in insulin resistant model rat. This observation provides theoretic basis for clinical and experimental studies of TCM.