Related Experiment Videos

[Preliminary study on relationship between TCM syndrome-type and insulin resistance in coronary heart disease]

W Mao1, W Ye, Q Liu

  • 1Zhejiang Provincial TCM Hospital, Hangzhou 310006.

Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine
|February 11, 2003
PubMed

Insights

Insulin resistance (ISR) is observed in coronary heart disease (CHD) patients, especially those with Heart Blood Stasis (HBS) and Phlegm-Turbid Stagnation (PTS) syndromes. Insulin antibodies (IAA) contribute to this resistance in some CHD patients.

Area of Science:

  • Integrative medicine
  • Cardiology
  • Endocrinology

Context:

  • Coronary heart disease (CHD) is a leading cause of mortality worldwide.
  • Insulin resistance (ISR) is a known risk factor for cardiovascular diseases.
  • Traditional Chinese Medicine (TCM) offers a unique perspective on disease patterns and treatment.

Purpose:

  • To investigate the association between specific TCM Syndrome-types and ISR in patients with CHD.
  • To compare metabolic parameters and insulin-related markers between CHD patients and healthy controls.

Summary:

  • Fifty CHD patients were classified into Heart Blood Stasis (HBS), Phlegm-Turbid Stagnation (PTS), and Qi-Yin Deficiency (QYD) syndrome groups.
  • CHD patients exhibited higher fasting blood glucose and insulin levels, and lower insulin sensitivity index (ISI) compared to controls.
  • HBS and PTS groups showed significantly lower ISI and higher insulin antibody (IAA) levels, with HBS also showing increased insulin levels and both groups presenting lipid disturbances.

Impact:

  • This study highlights that ISR is prevalent in a subset of CHD patients, particularly those diagnosed with HBS and PTS syndromes.
  • The presence of IAA in patient serum is identified as a contributing factor to ISR in these CHD patients.
  • Findings suggest potential for TCM-based diagnostics and therapeutic strategies targeting ISR in CHD management.
Abstract

Related Concept Videos

Type II Diabetes I: Introduction01:26

Type II Diabetes I: Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...