Related Experiment Video
Updated: Sep 27, 2026
A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection
Published on: February 28, 2019
[Effect of xiaoyin jiedu yin on Staphylococcus aureus enterotoxin B induced serum interleukin 8 in mice]
Objective:
To explore the therapeutic mechanism of Xiaoyin Jiedu Yin (XYJDY) in treating psoriasis.
Methods:
Abnormal elevation of interleukin 8 (IL-8) level in mice was induced by Staphylococcus aureus enterotoxin B (SEB), then the antagonizing effects of XYJDY and Composite Qingdai Capsule were observed.
Results:
Serum IL-8 level arose and reached the peak 3-5 hrs after SEB induction. XYJDY could antagonize the induction significantly, and the effect was more significant when large dosage was given.
Conclusion:
XYJDY, in either large or small dose, could effectively antagonize the SEB induction on IL-8. Applying with superantigen theory, this fact could be used to elucidate the mechanism of XYJDY in removing Heat, cooling blood and detoxifying at cell biologic level.
