Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Experimental study on effect of fuzheng yiliu decoction on tumor cell cycle and telomerease].

E L Dai1, J X Zhao, Y Z Zhu

  • 1Institute of Integrated Traditional and Westen Medicine of Lanzhou Medical College, Lanzhou 730000.

Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine
|February 11, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Intimate partner violence-mediated association between childhood sexual abuse and HIV infection risk among men who have sex with men].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2026
Same author

[Progress in the prevention and treatment of choledocho-pancreatico-duodenal-junction injury caused by ERCP].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2026
Same author

[Survival analysis in hepatitis C cases aged ≥18 years in Yuxi City from 2005 to 2023].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·2025
Same author

[Dose-dependent associations between screen time, contents and adolescents' mental health].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2025
Same author

Synovial chondromatosis in a patient with atypical rheumatoid arthritis confirmed by clinical, radiographic, and pathological evidence: a case report.

Scandinavian journal of rheumatology·2025
Same author

[Analysis of peripheral retinal defocus and wavefront aberrations in children with unilateral myopic anisometropia].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology·2025
Same journal

[Being Exposed to Specific Syndromes of Chinese Medicine and Being Compatible with Components of Chinese Herbs Are Important Ways to Control Toxicity of Toxic Chinese Herbs].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine·2019
Same journal

[Evaluating the Body of Evidence on Postmarketing Clinical Safety of Chinese Herbs].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine·2019
Same journal

[Overview and Future Thinking of Integrative Medicine].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine·2019
Same journal

[Effects of Huatan Tongluo Recipe on IL-1β-induced Proliferation of Rheumatoid Arthritis Synovial Fibroblasts and the Production of TNF-α and aFGF].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine·2019
Same journal

[Effect of Bushen Qiangdu Recipe on Histomorphology and Wnt Pathway of DBA/1 Mice].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine·2019
Same journal

[Ruyiping Inhibited Pulmonary Metastasis of Breast Cancer by Regulating the Formation of Pre-metastasis Microenvironment].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine·2019
See all related articles

Fuzheng Yiliu Decoction (FZYLD) inhibits tumor growth by blocking cell proliferation and DNA synthesis. This anti-tumor effect is linked to the suppression of telomerase activity in cancer cells.

Area of Science:

  • Oncology
  • Pharmacology
  • Molecular Biology

Context:

  • Traditional Chinese Medicine (TCM) offers potential anti-cancer agents.
  • Investigating the precise mechanisms of TCM in cancer treatment is crucial.
  • Fuzheng Yiliu Decoction (FZYLD) is a TCM formulation with reported anti-tumor properties.

Purpose:

  • To elucidate the anti-tumor mechanism of Fuzheng Yiliu Decoction (FZYLD).
  • To evaluate the effect of FZYLD on tumor cell cycle progression.
  • To assess the impact of FZYLD on telomerase activity in S180 solid tumors.

Summary:

  • S180 solid tumors were induced in Kunming mice and treated with FZYLD via oral gavage.
  • Flow cytometry analysis revealed an increased G0/1 phase cell ratio and decreased S phase cell ratio in FZYLD-treated tumors.

Related Experiment Videos

  • Telomerase activity was significantly inhibited in tumor cells following FZYLD administration compared to saline controls (P < 0.001).

    • Impact:

    • FZYLD demonstrates anti-proliferative effects on tumor cells.
    • FZYLD inhibits critical processes of DNA synthesis and duplication.
    • Suppression of telomerase activity is identified as a potential mechanism underlying FZYLD's anti-tumor action on the cell cycle.