Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ischemia and stroke.

Matthias Endres1, Ulrich Dirnagl

  • 1Experimental Neurology, Charit, Humboldt-University of Berlin, D-10098 Berlin, Germany.

Advances in Experimental Medicine and Biology
|February 11, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chemotherapy-induced cognitive impairment and its long-term development in patients with breast cancer: results from the observational CICARO study.

The oncologist·2024
Same author

Association Between Stroke Lesion Size and Atrial Fibrillation Detected After Stroke: An Observational Cohort Study.

Journal of the American Heart Association·2024
Same author

Timing of oral anticoagulation in atrial fibrillation patients after acute ischaemic stroke and outcome after 3 months: results of the multicentre Berlin Atrial Fibrillation Registry.

Open heart·2024
Same author

Refined movement analysis in the staircase test reveals differential motor deficits in mouse models of stroke.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2024
Same author

Impaired glucose metabolism and the risk of vascular events and mortality after ischemic stroke: A systematic review and meta-analysis.

Cardiovascular diabetology·2024
Same author

High serum prevalence of autoreactive IgG antibodies against peripheral nerve structures in patients with neurological post-COVID-19 vaccination syndrome.

Frontiers in immunology·2024
Same journal

Peptidomics in the Spotlight: Advanced Sample Treatment Techniques and Analytical Insights.

Advances in experimental medicine and biology·2026
Same journal

Methods for the Investigation of Protein-Ligands Interactions.

Advances in experimental medicine and biology·2026
Same journal

Sample Preparation Strategies for Microbial Cell Surface Proteomics: Integrating Shaving and Shotgun Approaches.

Advances in experimental medicine and biology·2026
Same journal

Proteomic Sample Preparation for the Petroleum Industry: A Biocorrosion Case Study.

Advances in experimental medicine and biology·2026
Same journal

Proteomic and Functional Comparison of Extracellular Vesicles from Wild-Type and Lyn-Deficient Stromal Cells.

Advances in experimental medicine and biology·2026
Same journal

Proteomic Analysis of Histone Sequence Variants and Post-translationally Modified Forms.

Advances in experimental medicine and biology·2026
See all related articles

Cell death after cerebral ischemia involves complex mechanisms like excitotoxicity and inflammation. Understanding these processes and using models of ischemia can help develop new neuroprotective strategies.

Area of Science:

  • Neuroscience
  • Pathophysiology
  • Cell Biology

Background:

  • Cerebral ischemia triggers a complex cascade of cell death mechanisms.
  • Identifying key mediators of ischemic brain damage is crucial for therapeutic development.

Purpose of the Study:

  • To outline the fundamental principles of cell death following cerebral ischemia.
  • To introduce in vitro and in vivo models for studying ischemic brain injury.
  • To identify the primary mechanisms driving neuronal damage in cerebral ischemia.

Main Methods:

  • Review of existing literature on cerebral ischemia.
  • Introduction of established in vitro models.
  • Description of in vivo experimental models.

Related Experiment Videos

Main Results:

  • Excitotoxicity, peri-infarct depolarization, inflammation, and apoptosis are identified as key mediators of cell death.
  • These mechanisms represent promising targets for neuroprotection.

Conclusions:

  • Cell death in cerebral ischemia is multifactorial, involving excitotoxicity, depolarization, inflammation, and apoptosis.
  • Targeting these specific pathways offers potential for developing effective neuroprotective therapies against ischemic stroke.