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Valproate unbound fraction and distribution volume following rapid infusions in patients with epilepsy
James C Cloyd1, Sandeep Dutta, Guoliang Cao
1College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.
Epilepsy Research
|February 11, 2003
Abstract:
The availability of an intravenous formulation now makes possible rapid administration of valproate (VPA) loading doses, but estimates of key VPA pharmacokinetic parameters in patients have limited the use of this approach. VPA disposition was characterized in 112 epilepsy patients, with or without enzyme inducing comedications, randomized to either 3.0 or 1.5mg/kg/min infusions of valproate sodium injection. Maximum dose was