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Related Experiment Videos

Changes in urine volume accomplished by physicians treating nephrolithiasis.

Joan H Parks1, Evan R Goldfischer, Frederic L Coe

  • 1Nephrology Section, University of Chicago, Illinois, USA.

The Journal of Urology
|February 11, 2003
PubMed
Summary

Increasing daily urine volume by 0.3 L modestly reduces calcium oxalate supersaturation. However, this benefit is partly offset by increased sodium and calcium excretion, necessitating vigilance against higher sodium intake with increased fluids.

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Area of Science:

  • Nephrology
  • Urology
  • Metabolic Disorders

Background:

  • Calcium oxalate stones are the most common type of kidney stone.
  • Urine supersaturation is a key factor in stone formation.
  • Fluid intake is a cornerstone of stone prevention strategies.

Purpose of the Study:

  • To quantify changes in urine volume and sodium in various clinical settings.
  • To assess the impact of these changes on calcium oxalate supersaturation.
  • To evaluate the effectiveness of fluid therapy in real-world practice.

Main Methods:

  • Analysis of comprehensive urine stone risk factors in 2,877 patients across 14 practices.
  • Measurement of changes in urine volume and stone risk factors.
  • Comparison of outcomes between a university referral center and private sector practices.

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Main Results:

  • A modest daily urine volume increase of approximately 0.3 L was observed across settings.
  • Urine sodium and calcium excretion increased with volume, partially counteracting the benefits.
  • Thiazide's effect on calcium excretion diminished with increased urine volume.

Conclusions:

  • Current clinical practice yields modest urine volume increases, often offset by increased sodium intake.
  • Higher urine volume increases are desirable for effective stone prevention.
  • Clinicians must monitor sodium intake closely when recommending increased fluid consumption.