[Anatomopathology of Paget's disease. Combined approach by conventional methods and ultrastructural study]

Paget's disease is manifested by bone remodelling where the rate of the resorption-osteogenesis pattern is abnormally enhanced. This leads to the formation of a pathologically structured bone. The bone remodelling does not concern the entire skeletal structure and is unequally active. It is limited by the neighbouring healthy bone in which it can spread out. It can be followed by the development of a sarcoma. When the acetabulum or the femoral head are affected this can occasionally, lead to a coxopathy with cartilage deterioration. An anatomo-pathological study of Paget's disease is necessary for understanding the basis and the limits of biopsy diagnosis as well as its various manifestations (clinical, radiological, biological, scintigraphical, thermographical). This study also serves as a basic for pathogenic discussion.