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Cytokines down-regulate alpha1-adrenergic receptor expression during endotoxemia.

Michael Bucher¹, Frieder Kees, Kai Taeger

¹Department of Anesthesiology, University of Regensburg, Germany. michael.bucher@klinik.uni-regensburg.de

Critical Care Medicine

|February 11, 2003

Summary

Sepsis reduces the body's response to norepinephrine by decreasing alpha1-adrenergic receptors. Proinflammatory cytokines, not nitric oxide, mediate this effect, contributing to septic shock.

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Failed At:

2026-06-19T13:31:39.212526+00:00

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