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Circadian pattern in cerebro vascular disorders

A Bhalla1, R Singh, A Sachdev

  • 1Department of Medicine, Government Medical College, Chandigarh - 160 032, India.

Neurology India
|February 11, 2003
PubMed

Insights

This study reveals circadian patterns in cerebrovascular disorders among Indians, with peak occurrences observed in the morning and early afternoon. Understanding these rhythms is crucial for managing stroke and transient ischemic attacks.

Area of Science:

  • Neurology
  • Cardiology
  • Chronobiology

Background:

  • Limited data exists on the circadian patterns of cardiovascular and cerebrovascular diseases within the Indian population.
  • Previous research has established circadian variations in these conditions globally.

Purpose of the Study:

  • To investigate the circadian variation in the occurrence of cerebrovascular disorders, specifically cerebrovascular accidents and transient ischemic attacks, in an Indian cohort.
  • To identify specific time windows with increased risk for these events.

Main Methods:

  • A prospective observational study was conducted.
  • 146 patient events (including cerebrovascular accidents and 10 transient ischemic attacks) were analyzed.
  • The 24-hour period was divided into six 4-hour intervals for analysis.

Main Results:

  • Cerebrovascular disorders exhibited a significant circadian variation.
  • Two distinct peaks in event occurrence were identified: 4 am to 8 am and 12 noon to 4 pm, each accounting for 23.28% of events.
  • The lowest incidence of events was observed between 12 midnight and 4 am (9.58%).
  • Hemorrhagic events constituted 55% and infarction 45% of the cases.

Conclusions:

  • The study confirms the presence of circadian variation in cerebrovascular disorders within the Indian population.
  • The findings highlight specific high-risk time periods, suggesting potential for targeted preventive strategies.
  • Further research is warranted to explore the underlying mechanisms and clinical implications of these circadian rhythms.

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