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Characterizing Exon Skipping Efficiency in DMD Patient Samples in Clinical Trials of Antisense Oligonucleotides
Published on: May 7, 2020
Detection of 1583 bp gene transcript in lymphocytes of muscular dystrophy patients
1Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh - 160 012, India.
Neurology India
|February 11, 2003
Abstract:
DMD and BMD are X-lined recessive disorders. RAP-PCR was utilized to investigate differentially expressed gene transcripts in lymphocytes from DMD, BMD and normal individuals as possible diagnostic parameter. A 1583 bp transcript was found to be expressed in both DMD and BMD patients which was unrelated to the known dystrophin gene. This may prove helpful in determining the carrier status of DMD/BMD.

