[Study on immunomodulating mechanism of the active fraction of liuwei dihuang decoction]
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1Beijing Institute of Pharmacology and Toxicology, Academy of Military Medicine, Beijing 100850.
Objective:
To investigate the immunomodulating mechanism of 3A, an active fraction extracted from the ethanol-soluble portion of Liuwei Dihuang Decoction (LWDHD).
Methods:
Influence of 3A on T-lymphocyte subsets, IgG production of B cells, interferon-gamma (IFN-gamma) mRNA expression in cyclophosphamide (Cy)-treated mice, tumor bearing mice and senescence accelerated mouse-prone/8 (SAMP8) were assessed in vivo and in vitro.
Results:
Oral administration of 3A could elevate the decreased T-lymphocyte subsets in all model mice, it also could promote the IgG secretion of splenic cells in SAMP8 and increase IFN-gamma mRNA expression in Cy-treated mice.
Conclusion:
The immunomodulating effect of 3A is related with its effects in regulating ratio of T and B cells or in improving their functions.
