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[Tissue insulin resistance and endothelial function of large vessels in patients with arterial hypertension]

F M Baĭramgulov, A D Bulgakova, M E Kurelenkova

    Terapevticheskii Arkhiv
    |February 13, 2003
    PubMed

    Insights

    Obese patients with high blood pressure often have insulin resistance and endothelial dysfunction, even before glucose tolerance issues arise. These conditions are linked to more severe lipid disturbances.

    Area of Science:

    • Cardiology
    • Endocrinology
    • Metabolic Syndrome

    Background:

    • Obesity and arterial hypertension (AH) are significant risk factors for cardiovascular disease.
    • Insulin resistance and endothelial dysfunction are increasingly recognized as key players in metabolic and cardiovascular health.

    Purpose of the Study:

    • To investigate insulin resistance and hyperinsulinemia in obese patients with moderate arterial hypertension (AH) but without diabetes, glucose intolerance, or ischemic heart disease.
    • To assess the endothelial vasomotor function of large vessels in this patient cohort.

    Main Methods:

    • Anthropometric measurements, glucose, immunoreactive insulin, C-peptide, and biochemical blood tests were performed on 41 males with AH.
    • Endothelial vasomotor function was evaluated using ultrasound.

    Main Results:

    • Insulin resistance was identified in 52.4% of hypertensive, obese patients, preceding abnormal glucose tolerance.
    • Patients with insulin resistance exhibited more pronounced lipid metabolic disturbances.
    • Endothelial vasomotor dysfunction was present, independent of insulin resistance status, with preserved arteriolar and capillary vasodilatation capacity.

    Conclusions:

    • Insulin resistance and endothelial dysfunction are highly prevalent in obese patients with hypertension.
    • These findings highlight the complex interplay between metabolic and vascular health in this population.
    Abstract

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