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[Tonocardin in complex treatment of diabetes mellitus concurrent with hypertension]

M I Balabolkin, E R Khasanova, T V Trukhina

    Terapevticheskii Arkhiv
    |February 13, 2003
    PubMed
    Abstract

    Insights

    Tonocardin (doxazosin) effectively lowers blood pressure and improves glucose and lipid metabolism in patients with type 2 diabetes and hypertension. This alpha-blocker also reduces insulin resistance, offering a comprehensive benefit for managing concurrent conditions.

    Area of Science:

    • Endocrinology
    • Cardiovascular Medicine
    • Pharmacology

    Background:

    • Arterial hypertension (AH) and type 2 diabetes mellitus (DM) frequently coexist, presenting complex management challenges.
    • Patients with concurrent AH and type 2 DM often exhibit dysregulated carbohydrate and lipid metabolism and insulin resistance.
    • Alpha-1-adrenoblockers are used to treat hypertension, but their effects on metabolic parameters in diabetic patients require further investigation.

    Purpose of the Study:

    • To evaluate the impact of the alpha-1-adrenoblocker tonocardin (doxazosin) on arterial hypertension (AH) in patients with type 2 diabetes mellitus (DM).
    • To assess the effects of tonocardin on carbohydrate metabolism, lipid metabolism, and insulin resistance in patients with concurrent AH and type 2 DM.

    Main Methods:

    • A study involving 18 patients diagnosed with both type 2 DM and AH.
    • Participants received tonocardin treatment for a minimum of 12 weeks.
    • Key metabolic and glycemic markers were measured, including fasting glycemia, glycosylated hemoglobin A1c, serum total cholesterol, triglycerides, and insulin resistance indices (HOMA method and insulin tolerance test).

    Main Results:

    • Tonocardin significantly reduced both systolic (14.5%) and diastolic (15.28%) blood pressure.
    • Treatment led to substantial improvements in glycemic control, decreasing fasting glycemia (24.36%) and glycosylated hemoglobin A1c (10.8%).
    • Significant reductions were observed in total cholesterol (11.4%), triglycerides (11%), and insulin resistance (33.5%), alongside improved glucose tolerance post-insulin load.

    Conclusions:

    • Tonocardin demonstrates a notable antihypertensive effect in patients with type 2 DM and AH.
    • The medication positively influences carbohydrate and lipid metabolism, improving key biochemical markers.
    • Tonocardin effectively diminishes insulin resistance, suggesting a multifaceted therapeutic benefit for this patient population.

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