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Updated: May 4, 2026

Experimental Human Pneumococcal Carriage
Published on: February 15, 2013
Variation in public and private supply of pneumococcal conjugate vaccine during a shortage
Gary L Freed1, Matthew M Davis, Sarah J Clark
1Division of General Pediatrics, University of Michigan, 300 N Ingalls 6E08, Ann Arbor, MI 48109-0456, USA. gfreed@umich.edu
Insights
During a 2001 heptavalent pneumococcal conjugate vaccine (PCV7) shortage, both public and private supplies varied significantly by state. Few practices altered vaccine administration policies despite CDC recommendations.
Area of Science:
- Immunization
- Vaccine Supply Chain Management
- Pediatric Public Health
Background:
- A significant shortage of heptavalent pneumococcal conjugate vaccine (PCV7) impacted 34 state immunization programs in late 2001.
- The Centers for Disease Control and Prevention (CDC) issued revised recommendations prioritizing PCV7 for specific pediatric groups.
- The impact of the PCV7 shortage at the healthcare practice level remained largely unknown.
Purpose of the Study:
- To investigate the disparities in PCV7 supply between public and private markets.
- To characterize the nature and extent of the PCV7 shortage experienced by healthcare practices.
Main Methods:
- Semistructured interviews were conducted with vaccine-ordering staff at 405 private practices across 12 states.
- Data collection occurred between October 19 and November 2, 2001.
- Vaccine supply was categorized as 'no problem,' 'problem obtaining a consistent supply,' or 'out of stock.'
Main Results:
- 51% of practices reported public PCV7 stockouts, and 64% reported private PCV7 stockouts, with considerable state-to-state variation.
- In most states studied, public PCV7 was less frequently out of stock than private PCV7.
- Only 23% of practices modified their private PCV7 administration policy, and 27% modified their public PCV7 policy.
Conclusions:
- PCV7 supply and distribution exhibited significant variability between public and private sources, as well as across different states during the shortage.
- Revised CDC recommendations for PCV7 prioritization had minimal impact on practice-level vaccine administration schedules.
Context:
In late August 2001, a serious shortage of the heptavalent pneumococcal conjugate vaccine (PCV7) developed in 34 state immunization programs. In September 2001, the Centers for Disease Control and Prevention published revised recommendations advising physicians to prioritize PCV7 to specific groups of children. The effect of the shortage at the practice level is unknown.
Objective:
To determine the variation between public and private markets in the supply of PCV7 and the nature and extent of the PCV7 shortage at the practice level.
Design, Setting, And Participants:
Semistructured interviews with office staff responsible for ordering vaccines at private practices in 12 states were conducted between October 19 and November 2, 2001.
Main Outcome Measures:
Variation in supply of PCV7 obtained from public sources and through purchase on the private market. Supply was characterized into 3 categories: "no problem," "problem obtaining a consistent supply," and "out of stock."
Results:
Interviews were completed at 405 practices, representing a response rate of 74%. Overall, 51% of practices reported at least 1 episode of being out of stock of public PCV7 and 64% of private PCV7, with significant state-to-state variation. Only 2 of 12 study states had a substantially higher proportion of practices experiencing out-of-stock episodes for public compared with private PCV7, while in 6 states public PCV7 was less frequently out of stock than private PCV7. Only 23% of practices in this study altered their administration policy for private PCV7, while 27% altered their policy for public PCV7.
Conclusions:
The distribution and supply of PCV7 varied between public and private supplies and between states during the shortage. Few practices changed their administration schedules in response to revised recommendations.
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