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Related Experiment Video

Updated: Jun 22, 2026

Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions

Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions

Published on: October 17, 2017

Association between plasma levels of monocyte chemoattractant protein-1 and long-term clinical outcomes in patients

James A de Lemos¹, David A Morrow, Marc S Sabatine

¹TIMI Study Group, Donald W. Reynolds Cardiovascular Clinical Research Center, the University of Texas, Southwestern Medical School, Dallas, TX 75390-9047, USA. james.delemos@utsouthwestern.edu

|February 13, 2003

Summary

Elevated monocyte chemoattractant protein-1 (MCP-1) levels in acute coronary syndrome patients correlate with traditional atherosclerosis risk factors and predict increased risk of death or myocardial infarction. MCP-1 shows potential as a biomarker and therapeutic target.

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Published on: January 28, 2020

Area of Science:

Cardiovascular Medicine
Inflammation Biology
Biomarker Discovery

Background:

Monocyte chemoattractant protein-1 (MCP-1) is a key chemokine in inflammatory responses.
MCP-1 plays a significant role in various stages of atherosclerosis development and progression.

Purpose of the Study:

To investigate the association between baseline MCP-1 levels and clinical characteristics in patients with acute coronary syndromes (ACS).
To determine if MCP-1 levels predict adverse cardiovascular outcomes in ACS patients.

Main Methods:

MCP-1 levels were measured in plasma from 2270 ACS patients (OPUS-TIMI 16 trial) and 279 healthy volunteers.
Statistical analyses were performed to correlate MCP-1 levels with baseline characteristics and outcomes, adjusting for confounders.

Main Results:

ACS patients had significantly higher median MCP-1 levels than healthy volunteers (178 vs. 157 pg/mL).
Elevated MCP-1 was associated with traditional risk factors: older age, female sex, hypertension, diabetes, prior coronary disease, and renal insufficiency.
High baseline MCP-1 (>75th percentile) independently predicted an increased risk of death or myocardial infarction at 10 months (aHR=1.53).

Conclusions:

Elevated MCP-1 in ACS patients is linked to established atherosclerosis risk factors and predicts poorer outcomes.
MCP-1 serves as a potential surrogate biomarker for cardiovascular risk.
MCP-1 warrants further investigation as a therapeutic target in cardiovascular disease.